I realize this may be a bit old, however if you are looking for closure, the error is produced because the application is looking for a file called Python.log that file exists in "the game folder" and then a subfolder called "profile". However, the application from your screenshot is looking is C:\Windows\System32\ instead of "the game folder". You probably tried to run a replay by right-clicking it and selecting the game for it to open. As the replay probably was in the wrong location (i.e. not the game folder), the game defaulted to look in the system directory, where it could not find the file in which to write. I am happy you found the solution, however. Now you know why it worked.
I just wanted to let you know, that studying your error, in turn, fixed my own. So thank you very much :)
